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ALTERATIONS IN CELLULAR PROCESSES

At its core, pathology is the study of disease. Diseases occur for many reasons. But some, such as cystic fibrosis and Parkinson’s Disease, occur because of alterations that prevent cells from functioning normally.

Understanding of signals and symptoms of alterations in cellular processes is a critical step in diagnosis and treatment of many diseases. For the Advanced Practice Registered Nurse (APRN), this understanding can also help educate patients and guide them through their treatment plans.

For this Discussion, you examine a case study and explain the disease that is suggested. You examine the symptoms reported and explain the cells that are involved and potential alterations and impacts. 

Week 1 Discussion Prompt:

An 83-year-old resident of a skilled nursing facility presents to the emergency department with generalized edema of extremities and abdomen. History obtained from staff reveals the patient has history of malabsorption syndrome and difficulty eating due to lack of dentures. The patient has been diagnosed with protein malnutrition.

To prepare:

By Day 1 of this week, you will be assigned to a specific scenario for this Discussion. Please see the “Course Announcements” section of the classroom for your assignment from your Instructor.

BY DAY 3 OF WEEK 1

Post an explanation of the disease highlighted in the scenario you were provided. Include the following in your explanation:

· The role genetics plays in the disease.

· Why the patient is presenting with the specific symptoms described.

· The physiologic response to the stimulus presented in the scenario and why you think this response occurred.

· The cells that are involved in this process.

· How another characteristic (e.g., gender, genetics) would change your response.

Read a selection of your colleagues’ responses.

· McCance, K. L. & Huether, S. E. (2019).  Pathophysiology: The biologic basis for disease in adults and children (8th ed.). St. Louis, MO: Mosby/Elsevier.

· Chapter 1: Cellular Biology; Summary Review

· Chapter 2: Altered Cellular and Tissue Biology: Environmental Agents (pp. 46-61; begin again with Manifestations of Cellular Injury pp. 83-97); Summary Review

· Chapter 3: The Cellular Environment: Fluids and Electrolytes, Acids, and Bases

· Chapter 4: Genes and Genetic Diseases (stop at Elements of formal genetics); Summary Review

· Chapter 5: Genes, Environment-Lifestyle, and Common Diseases (stop at Genetics of common diseases); Summary Review

· Justiz-Vaillant, A. A., & Zito, P. M. (2019).  Immediate hypersensitivity reactions  Download Immediate hypersensitivity reactions. In  StatPearls. Treasure Island, FL: StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/  Credit Line: Immediate Hypersensitivity Reactions – StatPearls – NCBI Bookshelf. (2019, June 18). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/. Used with permission of Stat Pearls

· Soo, P. (2018, July 28).  Pathophysiology Ch 10 alterations in immune functionLinks to an external site.  [Video file]. Retrieved from https://www.youtube.com/watch?v=Jz0wx1-jTds    Note: The approximate length of the media program is 37 minutes.

Hyponatremia

· MedCram. (2017, December 23).  Hyponatremia explained clearly (remastered) – Electrolyte imbalancesLinks to an external site.  [Video file]. Retrieved from https://www.youtube.com/watch?v=bLajK5Vy55M  Note: The approximate length of the media program is 15 minutes.